Synthesis of ribavirin 2’-Me-C-nucleoside analogues

Synthesis of ribavirin 2’-Me-C-nucleoside analogues

An efficient synthetic pathway leading to two carbonated analogues of ribavirin is described. The key-steps in the synthesis of these ribosyltriazoles bearing a quaternary carbon atom in the 2'-position are an indium-mediated alkynylation and a 1,3-dipolar cyclization.

Chemical Synthesis of Nucleoside Analogues Chemical Synthesis of Nucleoside Analogues

Synthesis of 1,2,3- Triazole Nucleoside Analogues

Both 1,2,3-triazoles and nucleosides have proved to be useful pharmacophores for antiviral and anticancer agents. A series of novel 1,2,3-triazole nucleoside analogues were designed and synthesized in order to find new antiviral or antitumor compounds. KEYWORD: Triazole; Nucleoside; Virus; Cancer International Conference on Industrial Technology and Management Science (ITMS 2015) © 2015. The au...

Convenient synthesis of nucleoside and isonucleoside analogues.

[reaction: see text]. A very simple methodology to stereoselectively achieve tricyclic isonucleosides (nucleobase = thymine, uracil, and 5-fluoruracil) and 3'-C-branched nucleosides (nucleobase = theophylline) was performed by means of a DBU-mediated addition process using a readily available 2-bromo sugar. The mechanism for these transformations implies the loss of both substituents at C-2 and...

Nucleoside Analogues: Synthesis from Strained Rings

Nucleoside analogues are widely employed as bioactive compounds against cancer and viral infections. Consequently, it is important to develop efficient synthetic methods to access them with high efficiency and structural diversity. Herein, we present a full account of our work on the synthesis of nucleoside analogues via annulations of donor acceptor aminocyclopropanes and aminocyclobutanes. Th...